Non-apoptotic cell dying resembling ferroptosis and pyroptosis has shed new gentle on most cancers remedy, whereas combinational remedy utilizing each these mechanisms has not but been absolutely explored. Herein, a dual-inductive nano-system to comprehend ferroptosis/pyroptosis mediated anti-cancer results is introduced. The nanodrug (Tf-LipoMof@PL) is constructed with a piperlongumine (PL) loaded metallic–natural framework (MOF) coated with transferrin adorned pH delicate lipid layer. Intracellular iron was enriched with an iron-containing MOF, whose endocytosis will be additional facilitated by transferrin adorned on the lipid layer, which supplies a prerequisite for the prevalence of ferroptosis and pyroptosis. Piperlongumine because the ferroptosis inducer can strengthen the ferroptotic cell dying, and supply H2O2 for the twin induction system to extend ROS technology by Fenton response. On the premise of validation of each ferroptosis and pyroptosis, the dual-inductive nanodrug demonstrated ideally suited anticancer results within the xenograft mice mannequin, which proved that the ferroptosis/pyroptosis dual-inductive nanoplatform could possibly be an efficient and promising anticancer modality.