Ligand-protected metallic nanoclusters managed by atomic accuracy (i. e. atomically exact metallic NCs) have not too long ago attracted appreciable consideration as energetic websites in heterogeneous catalysts. Utilizing these atomically exact metallic NCs, it turns into potential to create novel heterogeneous catalysts based mostly on a size-specific digital/geometrical construction of metallic NCs and perceive the mechanism of the catalytic response simply. Nonetheless, to create high-performance heterogeneous catalysts utilizing atomically exact metallic NCs, it’s typically essential to take away the ligands from the metallic NCs. This overview summarizes earlier research on the creation of heterogeneous catalysts utilizing atomically exact metallic NCs whereas specializing in the calcination as a ligand-elimination technique. Via this abstract, we intend to share state-of-art methods and data on 1) experimental circumstances appropriate for creating high-performance heterogeneous catalysts (e.g., assist kind, metallic NC kind, ligand kind, and calcination temperature), 2) the mechanism of calcination, and three) the mechanism of catalytic response over the created heterogeneous catalyst. We additionally talk about four) points that needs to be addressed sooner or later towards the creation of high-performance heterogeneous catalysts utilizing atomically exact metallic NCs. The data and points described on this overview are anticipated to result in clear design tips for the creation of novel heterogeneous catalysts.