Giant-scale fabrication of MXene movies is in excessive demand for numerous purposes, however it stays tough to satisfy industrial necessities. On this examine, we develop a slot-die coating technique for the preparation of large-area MXene membranes. The method permits the fabrication of steady and scalable coatings with a speedy coating pace of 6 mm s–1. The thickness could be readily managed from the nanometer scale to the micrometer scale, and the alignment of the nanosheet is enhanced by the shear pressure of the slot-die head. Molecular separation experiments using a movie with a thickness of roughly 100 nm are carried out. A nanofiltration efficiency with water permeance of 190 LMH/bar and molecular weight cutoff of 269 Da is achieved, surpassing beforehand reported outcomes obtained utilizing MXene-based nanofiltration membranes. The soundness of the membrane is highlighted by its nanofiltration efficiency of 30 days underneath harsh oxidizing circumstances, which is the longest operation ever achieved for a 2D material-based membrane. The extraordinary stability of the movie suggests its excessive potential for industrial and sensible purposes. The antioxidizing phenomena could be attributed to self-protection of the MXene floor by adsorbed natural molecules, that are significantly stabilized with positively charged molecules by way of chemisorption.