Our information on spider silks reveals the significance of becoming a member of heterogeneous constructions and floor chemical compositions in getting ready fibers, fibrous surfaces, and 3D supplies with a controllable wettability. We begin our evaluate with spider silk and proceed to the historic growth of nature-inspired spinning processes, their merchandise, and their benefits and downsides. Related wetting states are then summarized in fiber-based programs. Current functions are reviewed, together with one-dimensional spindle-knotted fibers for extremely environment friendly fog harvesting, long-distance transport, and stimulus-responsive wettability and two-dimensional spindle-knotted fibrous programs for water assortment, useful surfaces, and filtration. Lastly, we provide some perspective on future analysis traits concerning biomimetic fibers for wetting-controlled engineering.