Probing Multiscale Factors Affecting the Reactivity of Nanoparticle-Bound Molecules

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The constructions and physicochemical properties of surface-stabilizing molecules play a crucial position in defining the properties, interactions, and performance of hybrid nanomaterials similar to monolayer-stabilized nanoparticles. Concurrently, the distinct surface-bound interfacial setting imposes very particular situations on molecular reactivity and habits on this setting. Our means to probe hybrid nanoscale programs experimentally stays restricted, but understanding the results of floor confinement on molecular reactivity is essential for enabling predictive nanoparticle synthon approaches for postsynthesis engineering of nanoparticle floor chemistry and development of gadgets and supplies from nanoparticle parts. Right here, now we have undertaken an built-in experimental and computational examine of the response kinetics for nanoparticle-bound hydrazones, which give a prototypical platform for understanding chemical reactivity in a nanoconfined setting. Systematic variation of only one molecular-scale structural parameter—the space between reactive web site and nanoparticle floor—confirmed that the surface-bound reactivity is influenced by multiscale results. Nanoparticle-bound reactions had been tracked in situ utilizing 19F NMR spectroscopy, permitting direct comparability to the reactions of analogous substrates in bulk answer. The surface-confined reactions proceed extra slowly than their solution-phase counterparts, and kinetic inhibition turns into extra vital for reactive websites positioned nearer to the nanoparticle floor. Molecular dynamics simulations allowed us to establish distinct supramolecular architectures and sudden dynamic options of the surface-bound molecules that underpin the experimentally noticed developments in reactivity. This examine permits us to attract basic conclusions relating to interlinked structural and dynamical options throughout a number of size scales that affect interfacial reactivity in monolayer-confined environments.


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