Tailoring Supramolecular Prodrug Nanoassemblies for Reactive Nitrogen Species-Potentiated Chemotherapy of Liver Cancer

The event of a controllable reactive nitrogen species (RNS) era system for most cancers therapy has remained elusive. Herein, a supramolecular prodrug nanoassemblies (SPNA) technique that co-delivers a nitric oxide (NO) donor and a superoxide anion (O2•–) inducing chemotherapeutic agent was reported for RNS-potentiated chemotherapy. The mole ratio of platinum(IV) prodrug and NO donor might … Read more